Cancer from Hell: Devil Facial Tumour Disease
نویسندگان
چکیده
منابع مشابه
The Tasmanian Devil and Devil Facial Tumour Disease
The global extirpation of the world’s apex predator fauna is consistently highlighting their important functional role in preserving biodiversity and maintaining ecosystem resilience. Apex predator declines and extinctions are promoting more invasive and homogenised ecosystem states, linked with secondary species extinctions, changes to community composition, and redefined carnivore guilds. In ...
متن کاملTasmanian devil facial tumour disease: lessons for conservation biology.
Tasmanian devil facial tumour disease is an infectious cancer that threatens the largest surviving marsupial carnivore with extinction. After emerging in 1996, it has spread across most of the range of the species, leading to a population decline of more than 60%. This bizarre disease, in which the cancer cells themselves are the infective agent, illustrates some important general principles ab...
متن کاملExtensive population decline in the Tasmanian devil predates European settlement and devil facial tumour disease.
The Tasmanian devil (Sarcophilus harrisii) was widespread in Australia during the Late Pleistocene but is now endemic to the island of Tasmania. Low genetic diversity combined with the spread of devil facial tumour disease have raised concerns for the species' long-term survival. Here, we investigate the origin of low genetic diversity by inferring the species' demographic history using tempora...
متن کاملEvolution of a contagious cancer: epigenetic variation in Devil Facial Tumour Disease.
The emergence of Devil Facial Tumour Disease (DFTD), a highly contagious cancer, is driving Tasmanian devils (Sarcophilus harrisii) to extinction. The cancer is a genetically and chromosomally stable clonal cell line which is transmitted by biting during social interactions. In the present study, we explore the Devil Facial Tumour (DFT) epigenome and the genes involved in DNA methylation homeos...
متن کاملNew Insights into the Role of MHC Diversity in Devil Facial Tumour Disease
BACKGROUND Devil facial tumour disease (DFTD) is a fatal contagious cancer that has decimated Tasmanian devil populations. The tumour has spread without invoking immune responses, possibly due to low levels of Major Histocompatibility Complex (MHC) diversity in Tasmanian devils. Animals from a region in north-western Tasmania have lower infection rates than those in the east of the state. This ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2013
ISSN: 1664-3224
DOI: 10.3389/conf.fimmu.2013.02.00604